Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase

Although cellular prion protein PrP(C) is well known for its implication in Transmissible Spongiform Encephalopathies, its functions remain elusive. Combining in vitro and in vivo approaches, we here show that PrP(C) displays the intrinsic capacity to protect neuronal cells from a pro-inflammatory T...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ezpeleta, Juliette, Boudet-Devaud, François, Pietri, Mathéa, Baudry, Anne, Baudouin, Vincent, Alleaume-Butaux, Aurélie, Dagoneau, Nathalie, Kellermann, Odile, Launay, Jean-Marie, Schneider, Benoit
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550509/
https://ncbi.nlm.nih.gov/pubmed/28794434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08110-x
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