Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neurito...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Alleaume-Butaux, Aurélie, Nicot, Simon, Pietri, Mathéa, Baudry, Anne, Dakowski, Caroline, Tixador, Philippe, Ardila-Osorio, Hector, Haeberlé, Anne-Marie, Bailly, Yannick, Peyrin, Jean-Michel, Launay, Jean-Marie, Kellermann, Odile, Schneider, Benoit
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524729/
https://ncbi.nlm.nih.gov/pubmed/26241960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005073
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