Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neurito...

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Detaylı Bibliyografya
Yayımlandı:PLoS Pathog
Asıl Yazarlar: Alleaume-Butaux, Aurélie, Nicot, Simon, Pietri, Mathéa, Baudry, Anne, Dakowski, Caroline, Tixador, Philippe, Ardila-Osorio, Hector, Haeberlé, Anne-Marie, Bailly, Yannick, Peyrin, Jean-Michel, Launay, Jean-Marie, Kellermann, Odile, Schneider, Benoit
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524729/
https://ncbi.nlm.nih.gov/pubmed/26241960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005073
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