Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neurito...

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Opis bibliograficzny
Wydane w:PLoS Pathog
Główni autorzy: Alleaume-Butaux, Aurélie, Nicot, Simon, Pietri, Mathéa, Baudry, Anne, Dakowski, Caroline, Tixador, Philippe, Ardila-Osorio, Hector, Haeberlé, Anne-Marie, Bailly, Yannick, Peyrin, Jean-Michel, Launay, Jean-Marie, Kellermann, Odile, Schneider, Benoit
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2015
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524729/
https://ncbi.nlm.nih.gov/pubmed/26241960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005073
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