Reverse of Age-Dependent Memory Impairment and Mitochondrial DNA Damage in Microglia by an Overexpression of Human Mitochondrial Transcription Factor A in Mice

Mitochondrial DNA (mtDNA) is highly susceptible to injury induced by reactive oxygen species (ROS). During aging, mutations of mtDNA accumulate to induce dysfunction of the respiratory chain, resulting in the enhanced ROS production. Therefore, age-dependent memory impairment may result from oxidati...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Hayashi, Yoshinori, Yoshida, Masayoshi, Yamato, Mayumi, Ide, Tomomi, Wu, Zhou, Ochi-Shindou, Mayumi, Kanki, Tomotake, Kang, Dongchon, Sunagawa, Kenji, Tsutsui, Hiroyuki, Nakanishi, Hiroshi
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671051/
https://ncbi.nlm.nih.gov/pubmed/18716221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1957-08.2008
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