Mitophagy Plays an Essential Role in Reducing Mitochondrial Production of Reactive Oxygen Species and Mutation of Mitochondrial DNA by Maintaining Mitochondrial Quantity and Quality in Yeast

In mammalian cells, the autophagy-dependent degradation of mitochondria (mitophagy) is thought to maintain mitochondrial quality by eliminating damaged mitochondria. However, the physiological importance of mitophagy has not been clarified in yeast. Here, we investigated the physiological role of mi...

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Main Authors: Kurihara, Yusuke, Kanki, Tomotake, Aoki, Yoshimasa, Hirota, Yuko, Saigusa, Tetsu, Uchiumi, Takeshi, Kang, Dongchon
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270981/
https://ncbi.nlm.nih.gov/pubmed/22157017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280156
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