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The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the γ-Secretase

γ-Secretase is an unusual membrane-embedded protease, which cleaves the transmembrane domains (TMDs) of type I membrane proteins, including amyloid-β precursor protein and Notch receptor. We have previously shown the existence of a hydrophilic pore formed by TMD6 and TMD7 of presenilin 1 (PS1), the...

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Библиографические подробности
Опубликовано в: :J Neurosci
Главные авторы: Sato, Chihiro, Takagi, Shizuka, Tomita, Taisuke, Iwatsubo, Takeshi
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670534/
https://ncbi.nlm.nih.gov/pubmed/18550769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1163-08.2008
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