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Design and Optimization of Thioglycosyl–naphthalimides as Efficient Inhibitors Against Human O-GlcNAcase

β-N-acetylhexosaminidases represent an important class of exoglycosidases and have emerged as the promising targets for drug and pesticide discovery. Among these, human O-GlcNAcase (hOGA) has been reported to be closely linked to several diseases such as Alzheimer's disease, diabetes, and cance...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Shen, Shengqiang, Dong, Lili, Chen, Wei, Wu, Renjie, Lu, Huizhe, Yang, Qing, Zhang, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669961/
https://ncbi.nlm.nih.gov/pubmed/31403045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00533
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