Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor

Affinity mass spectrometry (MS) enables rapid screening of compound mixtures for ligands bound to a specific protein target, yet its current throughput is limited to individually assay pools of 400−2000 compounds. Typical affinity MS screens implemented in pharmaceutical industry laboratories identi...

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Publicado en:Anal Chem
Autores principales: Lu, Yan, Qin, Shanshan, Zhang, Bingjie, Dai, Antao, Cai, Xiaoqing, Ma, Mengna, Gao, Zhan-Guo, Yang, Dehua, Stevens, Raymond C., Jacobson, Kenneth A., Wang, Ming-Wei, Shui, Wenqing
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669887/
https://ncbi.nlm.nih.gov/pubmed/31094506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b00477
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