Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics Approaches

The nucleoprotein (NP) of Ebola virus (EBOV) and Marburg virus (MARV) is an essential component of the viral ribonucleoprotein complex and significantly impacts replication and transcription of the viral RNA genome. Although NP is regarded as a promising antiviral druggable target, no chemical ligan...

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Udgivet i:Sci Rep
Main Authors: Fu, Xu, Wang, Zhihua, Li, Lixin, Dong, Shishang, Li, Zhucui, Jiang, Zhenzuo, Wang, Yuefei, Shui, Wenqing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940736/
https://ncbi.nlm.nih.gov/pubmed/27403722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29680
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