RUNX1 inhibits proliferation and induces apoptosis of t(8;21) leukemia cells via KLF4-mediated transactivation of P57

RUNX1 is a key transcription factor in hematopoiesis and its disruption is one of the most common aberrations in acute myeloid leukemia. RUNX1 alterations affect its DNA binding capacity and transcriptional activities, leading to the deregulation of transcriptional targets, and abnormal proliferatio...

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Publicado en:Haematologica
Main Authors: Liu, Shuang, Xing, Yanyan, Lu, Wenting, Li, Shouyun, Tian, Zheng, Xing, Haiyan, Tang, Kejing, Xu, Yingxi, Rao, Qing, Wang, Min, Wang, Jianxiang
Formato: Artigo
Idioma:Inglês
Publicado: Ferrata Storti Foundation 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669147/
https://ncbi.nlm.nih.gov/pubmed/30792202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.192773
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