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Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca(2+)
NAADP potently triggers Ca(2+) release from acidic lysosomal and endolysosomal Ca(2+) stores. Human two-pore channels (TPC1 and TPC2), which are located on these stores, are involved in this process but there is controversy over whether TPC1 and TPC2 constitute the Ca(2+) release channels. We, there...
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| Publicat a: | Sci Signal |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6669042/ https://ncbi.nlm.nih.gov/pubmed/24847115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004854 |
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