TPC2 Is a Novel NAADP-sensitive Ca(2+) Release Channel, Operating as a Dual Sensor of Luminal pH and Ca(2+)

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a molecule capable of initiating the release of intracellular Ca(2+) required for many essential cellular processes. Recent evidence links two-pore channels (TPCs) with NAADP-induced release of Ca(2+) from lysosome-like acidic organelles; howe...

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Detalhes bibliográficos
Main Authors: Pitt, Samantha J., Funnell, Tim M., Sitsapesan, Mano, Venturi, Elisa, Rietdorf, Katja, Ruas, Margarida, Ganesan, A., Gosain, Rajendra, Churchill, Grant C., Zhu, Michael X., Parrington, John, Galione, Antony, Sitsapesan, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966118/
https://ncbi.nlm.nih.gov/pubmed/20720007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156927
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