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Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca(2+)
NAADP potently triggers Ca(2+) release from acidic lysosomal and endolysosomal Ca(2+) stores. Human two-pore channels (TPC1 and TPC2), which are located on these stores, are involved in this process but there is controversy over whether TPC1 and TPC2 constitute the Ca(2+) release channels. We, there...
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| Yayımlandı: | Sci Signal |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6669042/ https://ncbi.nlm.nih.gov/pubmed/24847115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004854 |
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