Recurrent tumor cell-intrinsic and -extrinsic alterations during MAPKi-induced melanoma regression and early adaptation

Treatment of advanced (V600)BRAF mutant melanoma using a BRAF inhibitor (BRAFi) or its combination with a MEKi typically elicits partial responses. We compared the transcriptomes of patient-derived tumors regressing on MAPKi therapy against MAPKi-induced temporal transcriptomic states in human melan...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Song, Chunying, Piva, Marco, Sun, Lu, Hong, Aayoung, Moriceau, Gatien, Kong, Xiangju, Zhang, Hong, Lomeli, Shirley, Qian, Jin, Yu, Clarissa C., Damoiseaux, Robert, Kelley, Mark C., Dahlman, Kimberley B., Scumpia, Philip O., Sosman, Jeffrey A., Johnson, Douglas B., Ribas, Antoni, Hugo, Willy, Lo, Roger S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668729/
https://ncbi.nlm.nih.gov/pubmed/28864476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0401
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