Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colon carcinoma HCT116 cells mediated by JNK/p38/ERK1/2 via a p53-independent signaling

Ru(II)-thymine complex [Ru(PPh(3))(2)(Thy)(bipy)]PF(6) (where PPh(3) = triphenylphosphine, Thy = thyminate and bipy = 2,2′-bipyridine) is a potent cytotoxic agent with ability to bind to DNA, inducing caspase-mediated apoptosis in leukemia cells. In this study, we investigated the mechanism underlyi...

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Pubblicato in:Sci Rep
Autori principali: Silva, Suellen L. R., Baliza, Ingrid R. S., Dias, Rosane B., Sales, Caroline B. S., Rocha, Clarissa A. Gurgel, Soares, Milena B. P., Correa, Rodrigo S., Batista, Alzir A., Bezerra, Daniel P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668648/
https://ncbi.nlm.nih.gov/pubmed/31366902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47539-0
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