Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells

Ruthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)(2)(PPh(3))(2)] (1) and [Ru(6m2tu)(2)(dppb)] (2) (where PPh(3 = )triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study wa...

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Vydáno v:Sci Rep
Hlavní autoři: Bomfim, Larissa M., de Araujo, Fênix A., Dias, Rosane B., Sales, Caroline B. S., Rocha, Clarissa A. Gurgel, Correa, Rodrigo S., Soares, Milena B. P., Batista, Alzir A., Bezerra, Daniel P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686011/
https://ncbi.nlm.nih.gov/pubmed/31391500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47914-x
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