Miltefosine increases macrophage cholesterol release and inhibits NLRP3-inflammasome assembly and IL-1β release

Miltefosine is an FDA approved oral drug for treating cutaneous and visceral leishmaniasis. Leishmania is a flagellated protozoa, which infects and differentiates in macrophages. Here, we studied the effects of Miltefosine on macrophage’s lipid homeostasis, autophagy, and NLRP3 inflammasome assembly...

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Vydáno v:Sci Rep
Hlavní autoři: Iacano, Amanda J., Lewis, Harvey, Hazen, Jennie E., Andro, Heather, Smith, Jonathan D., Gulshan, Kailash
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668382/
https://ncbi.nlm.nih.gov/pubmed/31366948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47610-w
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