Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages

Lysosomal cathepsin B (CTSB) has been proposed to play a role in the induction of acute inflammation. We hypothesised that the presence of active CTSB in the cytosol is crucial for NLRP3-inflammasome assembly and, consequently, for mature IL-1β generation after mycobacterial infection in vitro. Elev...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Amaral, Eduardo P., Riteau, Nicolas, Moayeri, Mahtab, Maier, Nolan, Mayer-Barber, Katrin D., Pereira, Rosana M., Lage, Silvia L., Kubler, Andre, Bishai, William R., D’Império-Lima, Maria R., Sher, Alan, Andrade, Bruno B.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021483/
https://ncbi.nlm.nih.gov/pubmed/29977244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01427
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados