Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that regulates inflammatory responses to injury and infection. IL-1β secretion requires the protease caspase-1, which is activated following recruitment to inflammasomes. Endogenous danger-associated molecular patterns (DAMPs) released from necro...

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Bibliografiske detaljer
Main Authors: Luheshi, Nadia M, Giles, James A, Lopez-Castejon, Gloria, Brough, David
Format: Artigo
Sprog:Inglês
Udgivet: WILEY-VCH Verlag 2012
Fag:
Innate Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491674/
https://ncbi.nlm.nih.gov/pubmed/22105559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201142079
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