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Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382995/ https://ncbi.nlm.nih.gov/pubmed/25800347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7555 |
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