Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine...

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Publicat a:Nat Commun
Autors principals: Ives, Annette, Nomura, Johji, Martinon, Fabio, Roger, Thierry, LeRoy, Didier, Miner, Jeffrey N., Simon, Gregoire, Busso, Nathalie, So, Alexander
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382995/
https://ncbi.nlm.nih.gov/pubmed/25800347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7555
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