Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation

A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction. Upon oligomerization of apoptosis-associated speck-like protein con...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Castelblanco, Mariela, Lugrin, Jérôme, Ehirchiou, Driss, Nasi, Sonia, Ishii, Isao, So, Alexander, Martinon, Fabio, Busso, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818172/
https://ncbi.nlm.nih.gov/pubmed/29279328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806869
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