Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Ives, Annette, Nomura, Johji, Martinon, Fabio, Roger, Thierry, LeRoy, Didier, Miner, Jeffrey N., Simon, Gregoire, Busso, Nathalie, So, Alexander
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Pub. Group 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382995/
https://ncbi.nlm.nih.gov/pubmed/25800347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7555
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