Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)

The L-type amino acid transporter 1 (LAT1, SLC7A5) transports essential amino acids across the blood—brain barrier (BBB) and into cancer cells. To utilize LAT1 for drug delivery, potent amino acid promoieties are desired, as prodrugs must compete with millimolar concentrations of endogenous amino ac...

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Publicat a:J Med Chem
Autors principals: Chien, Huan-Chieh, Colas, Claire, Finke, Karissa, Springer, Seth, Stoner, Laura, Zur, Arik A., Venteicher, Brooklynn, Campbell, Jerome, Hall, Colton, Flint, Andrew, Augustyn, Evan, Hernandez, Christopher, Heeren, Nathan, Hansen, Logan, Anthony, Abby, Bauer, Justine, Fotiadis, Dimitrios, Schlessinger, Avner, Giacomini, Kathleen M., Thomas, Allen A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668346/
https://ncbi.nlm.nih.gov/pubmed/30048132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01007
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