A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans

BACKGROUND: Candidemia, one of the most common causes of fungal bloodstream infection, leads to mortality rates up to 40% in affected patients. Understanding genetic mechanisms for differential susceptibility to candidemia may aid in designing host-directed therapies. METHODS: We performed the first...

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Publicat a:J Infect Dis
Autors principals: Jaeger, Martin, Matzaraki, Vasiliki, Aguirre-Gamboa, Raúl, Gresnigt, Mark S, Chu, Xiaojing, Johnson, Melissa D, Oosting, Marije, Smeekens, Sanne P, Withoff, Sebo, Jonkers, Iris, Perfect, John R, van de Veerdonk, Frank L, Kullberg, Bart-Jan, Joosten, Leo A B, Li, Yang, Wijmenga, Cisca, Netea, Mihai G, Kumar, Vinod
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667794/
https://ncbi.nlm.nih.gov/pubmed/31241743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz206
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