From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases

door Kumar, Vinod, Wijmenga, Cisca, Withoff, Sebo
Gepubliceerd in 2012

Celiac disease-on-chip: Modeling a multifactorial disease in vitro

door Moerkens, Renée, Mooiweer, Joram, Withoff, Sebo, Wijmenga, Cisca
Gepubliceerd in United European Gastroenterol J (2019)

Small and Long Regulatory RNAs in the Immune System and Immune Diseases

door Stachurska, Anna, Zorro, Maria M., van der Sijde, Marijke R., Withoff, Sebo
Gepubliceerd in 2014

Intestinal Barrier Function in Gluten-Related Disorders

door Cardoso-Silva, Danielle, Delbue, Deborah, Itzlinger, Alice, Moerkens, Renée, Withoff, Sebo, Branchi, Federica, Schumann, Michael
Gepubliceerd in Nutrients (2019)

THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge

door Bondar, Constanza, Plaza-Izurieta, Leticia, Fernandez-Jimenez, Nora, Irastorza, Iñaki, Withoff, Sebo, Wijmenga, Cisca, Chirdo, Fernando, Bilbao, Jose Ramon
Gepubliceerd in 2014

Molecular Biomarkers for Celiac Disease: Past, Present and Future

door Ramírez-Sánchez, Aarón D., Tan, Ineke L., Gonera-de Jong, B.C., Visschedijk, Marijn C., Jonkers, Iris, Withoff, Sebo
Gepubliceerd in Int J Mol Sci (2020)

Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage

door Spierings, Diana C., McGoldrick, Daniel, Hamilton-Easton, Ann Marie, Neale, Geoffrey, Murchison, Elizabeth P., Hannon, Greg J., Green, Douglas R., Withoff, Sebo
Gepubliceerd in 2011

Leukocyte-Released Mediators in Response to Both Bacterial and Fungal Infections Trigger IFN Pathways, Independent of IL-1 and TNF-α, in Endothelial Cells

door Le, Kieu T. T., Chu, Xiaojing, Jaeger, Martin, Plantinga, Josée A., Matzaraki, Vasiliki, Withoff, Sebo, Joosten, Leo A. B., Netea, Mihai G., Wijmenga, Cisca, Li, Yang, Moser, Jill, Kumar, Vinod
Gepubliceerd in Front Immunol (2019)

Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes

door Zorro, Maria Magdalena, Aguirre-Gamboa, Raul, Mayassi, Toufic, Ciszewski, Cezary, Barisani, Donatella, Hu, Shixian, Weersma, Rinse K, Withoff, Sebo, Li, Yang, Wijmenga, Cisca, Jabri, Bana, Jonkers, Iris H
Gepubliceerd in J Autoimmun (2020)

Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity

door Hrdlickova, Barbara, Kumar, Vinod, Kanduri, Kartiek, Zhernakova, Daria V, Tripathi, Subhash, Karjalainen, Juha, Lund, Riikka J, Li, Yang, Ullah, Ubaid, Modderman, Rutger, Abdulahad, Wayel, Lähdesmäki, Harri, Franke, Lude, Lahesmaa, Riitta, Wijmenga, Cisca, Withoff, Sebo
Gepubliceerd in Genome Med (2014)

Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression

door Kumar, Vinod, Westra, Harm-Jan, Karjalainen, Juha, Zhernakova, Daria V., Esko, Tõnu, Hrdlickova, Barbara, Almeida, Rodrigo, Zhernakova, Alexandra, Reinmaa, Eva, Võsa, Urmo, Hofker, Marten H., Fehrmann, Rudolf S. N., Fu, Jingyuan, Withoff, Sebo, Metspalu, Andres, Franke, Lude, Wijmenga, Cisca
Gepubliceerd in 2013

An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility

door Matzaraki, Vasiliki, Gresnigt, Mark S., Jaeger, Martin, Ricaño-Ponce, Isis, Johnson, Melissa D., Oosting, Marije, Franke, Lude, Withoff, Sebo, Perfect, John R., Joosten, Leo A. B., Kullberg, Bart Jan, van de Veerdonk, Frank L., Jonkers, Iris, Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Kumar, Vinod
Gepubliceerd in PLoS One (2017)

A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans

door Jaeger, Martin, Matzaraki, Vasiliki, Aguirre-Gamboa, Raúl, Gresnigt, Mark S, Chu, Xiaojing, Johnson, Melissa D, Oosting, Marije, Smeekens, Sanne P, Withoff, Sebo, Jonkers, Iris, Perfect, John R, van de Veerdonk, Frank L, Kullberg, Bart-Jan, Joosten, Leo A B, Li, Yang, Wijmenga, Cisca, Netea, Mihai G, Kumar, Vinod
Gepubliceerd in J Infect Dis (2019)

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses

door Bakker, Olivier B., Aguirre-Gamboa, Raul, Sanna, Serena, Oosting, Marije, Smeekens, Sanne P., Jaeger, Martin, Zorro, Maria, Võsa, Urmo, Withoff, Sebo, Netea-Maier, Romana T., Koenen, Hans J.P.M., Joosten, Irma, Xavier, Ramnik J., Franke, Lude, Joosten, Leo A.B., Kumar, Vinod, Wijmenga, Cisca, Netea, Mihai G., Li, Yang
Gepubliceerd in Nat Immunol (2018)

Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease

door van der Graaf, Adriaan, Zorro, Maria M., Claringbould, Annique, Võsa, Urmo, Aguirre-Gamboa, Raúl, Li, Chan, Mooiweer, Joram, Ricaño-Ponce, Isis, Borek, Zuzanna, Koning, Frits, Kooy-Winkelaar, Yvonne, Sollid, Ludvig M., Qiao, Shuo-Wang, Kumar, Vinod, Li, Yang, Franke, Lude, Withoff, Sebo, Wijmenga, Cisca, Sanna, Serena, Jonkers, Iris
Gepubliceerd in Front Genet (2021)

Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells

door Bakker, Olivier B., Ramírez-Sánchez, Aarón D., Borek, Zuzanna A., de Klein, Niek, Li, Yang, Modderman, Rutger, Kooy-Winkelaar, Yvonne, Johannesen, Marie K., Matarese, Filomena, Martens, Joost H. A., Kumar, Vinod, van Bergen, Jeroen, Qiao, Shuo-Wang, Lundin, Knut E. A., Sollid, Ludvig M., Koning, Frits, Wijmenga, Cisca, Withoff, Sebo, Jonkers, Iris H.
Gepubliceerd in Sci Rep (2021)

Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant

door Almeida, Rodrigo, Ricaño-Ponce, Isis, Kumar, Vinod, Deelen, Patrick, Szperl, Agata, Trynka, Gosia, Gutierrez-Achury, Javier, Kanterakis, Alexandros, Westra, Harm-Jan, Franke, Lude, Swertz, Morris A., Platteel, Mathieu, Bilbao, Jose Ramon, Barisani, Donatella, Greco, Luigi, Mearin, Luisa, Wolters, Victorien M., Mulder, Chris, Mazzilli, Maria Cristina, Sood, Ajit, Cukrowska, Bozena, Núñez, Concepción, Pratesi, Riccardo, Withoff, Sebo, Wijmenga, Cisca
Gepubliceerd in 2014

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidemia

door Kumar, Vinod, Cheng, Shih-Chin, Johnson, Melissa D., Smeekens, Sanne P., Wojtowicz, Agnieszka, Giamarellos-Bourboulis, Evangelos, Karjalainen, Juha, Franke, Lude, Withoff, Sebo, Plantinga, Theo S., van de Veerdonk, Frank L., van der Meer, Jos W.M., Joosten, Leo A.B., Bochud, Pierre-Yves, Marchetti, Oscar, Perfect, John R., Xavier, Ramnik, Kullberg, Bart Jan, Wijmenga, Cisca, Netea, Mihai G.
Gepubliceerd in Nat Commun (2014)

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

door Ricaño-Ponce, Isis, Zhernakova, Daria V., Deelen, Patrick, Luo, Oscar, Li, Xingwang, Isaacs, Aaron, Karjalainen, Juha, Di Tommaso, Jennifer, Borek, Zuzanna Agnieszka, Zorro, Maria M., Gutierrez-Achury, Javier, Uitterlinden, Andre G., Hofman, Albert, van Meurs, Joyce, Netea, Mihai G., Jonkers, Iris H., Withoff, Sebo, van Duijn, Cornelia M., Li, Yang, Ruan, Yijun, Franke, Lude, Wijmenga, Cisca, Kumar, Vinod
Gepubliceerd in J Autoimmun (2016)

A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease

door Hrdlickova, Barbara, Mulder, Chris J., Malamut, Georgia, Meresse, Bertrand, Platteel, Mathieu, Kamatani, Yoichiro, Ricaño-Ponce, Isis, van Wanrooij, Roy L.J., Zorro, Maria M., Bonder, Marc Jan, Gutierrez-Achury, Javier, Cellier, Christophe, Zhernakova, Alexandra, Nijeboer, Petula, Galan, Pilar, Withoff, Sebo, Lathrop, Mark, Bouma, Gerd, Xavier, Ramnik J., Jabri, Bana, Bensussan, Nadine C., Wijmenga, Cisca, Kumar, Vinod
Gepubliceerd in Eur J Gastroenterol Hepatol (2018)