Increase in DNA Damage by MYCN Knockdown Through Regulating Nucleosome Organization and Chromatin State in Neuroblastoma

As a transcription factor, MYCN regulates myriad target genes including the histone chaperone FACT. Moreover, FACT and MYCN expression form a forward feedback loop in neuroblastoma. It is unclear whether MYCN is involved in chromatin remodeling in neuroblastoma through regulation of its target genes...

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Udgivet i:Front Genet
Main Authors: Hu, Xinjie, Zheng, Weisheng, Zhu, Qianshu, Gu, Liang, Du, Yanhua, Han, Zhe, Zhang, Xiaobai, Carter, Daniel R., Cheung, Belamy B., Qiu, Andong, Jiang, Cizhong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667652/
https://ncbi.nlm.nih.gov/pubmed/31396265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00684
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