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Profiling host ANP32A splicing landscapes to predict influenza A virus polymerase adaptation
Species’ differences in cellular factors limit avian influenza A virus (IAV) zoonoses and human pandemics. The IAV polymerase, vPol, harbors evolutionary sites to overcome restriction and determines virulence. Here, we establish host ANP32A as a critical driver of selection, and identify host-specif...
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| Publicado no: | Nat Commun |
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| Principais autores: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6667478/ https://ncbi.nlm.nih.gov/pubmed/31363119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11388-2 |
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