Profiling host ANP32A splicing landscapes to predict influenza A virus polymerase adaptation

Species’ differences in cellular factors limit avian influenza A virus (IAV) zoonoses and human pandemics. The IAV polymerase, vPol, harbors evolutionary sites to overcome restriction and determines virulence. Here, we establish host ANP32A as a critical driver of selection, and identify host-specif...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Domingues, Patricia, Eletto, Davide, Magnus, Carsten, Turkington, Hannah L., Schmutz, Stefan, Zagordi, Osvaldo, Lenk, Matthias, Beer, Martin, Stertz, Silke, Hale, Benjamin G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667478/
https://ncbi.nlm.nih.gov/pubmed/31363119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11388-2
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