Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA replication and protein translation, are lethal for the parasite, and several (doxycycline, clindamycin, and azithromycin) are in clinical use...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Kennedy, Kit, Cobbold, Simon A., Hanssen, Eric, Birnbaum, Jakob, Spillman, Natalie J., McHugh, Emma, Brown, Hannah, Tilley, Leann, Spielmann, Tobias, McConville, Malcolm J., Ralph, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667170/
https://ncbi.nlm.nih.gov/pubmed/31318858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000376
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