Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA replication and protein translation, are lethal for the parasite, and several (doxycycline, clindamycin, and azithromycin) are in clinical use...

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Udgivet i:PLoS Biol
Main Authors: Kennedy, Kit, Cobbold, Simon A., Hanssen, Eric, Birnbaum, Jakob, Spillman, Natalie J., McHugh, Emma, Brown, Hannah, Tilley, Leann, Spielmann, Tobias, McConville, Malcolm J., Ralph, Stuart A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667170/
https://ncbi.nlm.nih.gov/pubmed/31318858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000376
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