Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the hypothalamus plays an important role in maintenance of energy homeostasis. While Stat3 activation in POMC neurons is required for POMC expression, the role of elevated basal Stat3 activation as present in the...

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Pubblicato in:J Neurosci
Autori principali: Ernst, Marianne B., Wunderlich, Claudia M., Hess, Simon, Paehler, Moritz, Mesaros, Andrea, Koralov, Sergei B., Kleinridders, André, Husch, Andreas, Münzberg, Heike, Hampel, Brigitte, Alber, Jens, Kloppenburg, Peter, Brüning, Jens C., Wunderlich, F. Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665760/
https://ncbi.nlm.nih.gov/pubmed/19759305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5712-08.2009
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