Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the hypothalamus plays an important role in maintenance of energy homeostasis. While Stat3 activation in POMC neurons is required for POMC expression, the role of elevated basal Stat3 activation as present in the...

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書誌詳細
出版年:J Neurosci
主要な著者: Ernst, Marianne B., Wunderlich, Claudia M., Hess, Simon, Paehler, Moritz, Mesaros, Andrea, Koralov, Sergei B., Kleinridders, André, Husch, Andreas, Münzberg, Heike, Hampel, Brigitte, Alber, Jens, Kloppenburg, Peter, Brüning, Jens C., Wunderlich, F. Thomas
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2009
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665760/
https://ncbi.nlm.nih.gov/pubmed/19759305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5712-08.2009
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