Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the hypothalamus plays an important role in maintenance of energy homeostasis. While Stat3 activation in POMC neurons is required for POMC expression, the role of elevated basal Stat3 activation as present in the...

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Publicado no:J Neurosci
Main Authors: Ernst, Marianne B., Wunderlich, Claudia M., Hess, Simon, Paehler, Moritz, Mesaros, Andrea, Koralov, Sergei B., Kleinridders, André, Husch, Andreas, Münzberg, Heike, Hampel, Brigitte, Alber, Jens, Kloppenburg, Peter, Brüning, Jens C., Wunderlich, F. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665760/
https://ncbi.nlm.nih.gov/pubmed/19759305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5712-08.2009
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