Human APOE Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice

To investigate the role of human apolipoprotein E (apoE) on Aβ deposition in vivo, we crossed PDAPP mice lacking mouse Apoe to targeted replacement mice expressing human apoE (PDAPP/TRE2, PDAPP/TRE3, or PDAPP/TRE4). We then measured the levels of apoE protein and Aβ peptides in plasma, CSF, and brai...

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Publicat a:J Neurosci
Autors principals: Bales, Kelly R., Liu, Feng, Wu, Su, Lin, Suizhen, Koger, Deanna, DeLong, Cynthia, Hansen, Jeffrey C., Sullivan, Patrick M., Paul, Steven M.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665579/
https://ncbi.nlm.nih.gov/pubmed/19474305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0887-09.2009
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