Macrophage-Mediated Degradation of β-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism

Recent studies suggest that bone marrow-derived macrophages can effectively reduce β-amyloid (Aβ) deposition in brain. To further elucidate the mechanisms by which macrophages degrade Aβ, we cultured murine macrophages on top of Aβ plaque-bearing brain sections from transgenic mice expressing PDAPP...

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Publicado en:J Neurosci
Main Authors: Zhao, Lingzhi, Lin, Suizhen, Bales, Kelly R., Gelfanova, Valentina, Koger, Deanna, DeLong, Cynthia, Hale, John, Liu, Feng, Hunter, Jesse M., Paul, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665249/
https://ncbi.nlm.nih.gov/pubmed/19295164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5302-08.2009
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