A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients

Huntington’s disease (HD) is a progressive neurodegenerative disease. Involuntary movements, cognitive impairment and psychiatric disturbance are the major clinical manifestations, and gradual atrophy and selective neuronal loss in the striatum and cerebral cortex are the pathologic hallmarks. HD is...

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Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: Liu, Peng, Smith, Benjamin R., Huang, Eric S., Mahesh, Abhishek, Vonsattel, Jean Paul G., Petersen, Ashley J., Gomez-Pastor, Rocio, Ashe, Karen H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664763/
https://ncbi.nlm.nih.gov/pubmed/31358058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0764-9
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