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Caspase-Mediated Truncation of Tau Potentiates Aggregation
Caspase-mediated truncation of tau is associated with aggregation. We examined the impact of manipulation of caspase activity on intracellular aggregation of a mutant form of tau (3PO) that forms spontaneous aggregates. Treatment with the caspase inhibitor Z-VAD-fmk reduced both N and C-terminal tau...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Hindawi Publishing Corporation
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3440879/ https://ncbi.nlm.nih.gov/pubmed/22988541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/731063 |
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