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The abundant DNA adduct N(7)-methyl deoxyguanosine contributes to miscoding during replication by human DNA polymerase η
Aside from abasic sites and ribonucleotides, the DNA adduct N(7)-methyl deoxyguanosine (N(7)-CH(3) dG) is one of the most abundant lesions in mammalian DNA. Because N(7)-CH(3) dG is unstable, leading to deglycosylation and ring-opening, its miscoding potential is not well-understood. Here, we employ...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6664181/ https://ncbi.nlm.nih.gov/pubmed/31101656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008986 |
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