The key genes, phosphoproteins, processes, and pathways affected by efavirenz-activated CYP46A1 in the amyloid-decreasing paradigm of efavirenz treatment

Efavirenz (EFV) is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is the major brain cholesterol hydroxylase. Previously, we discovered that EFV activates CYP46A1 and improves behavioral performance in 5XFAD mice, an Alzheimer’s disease model. Herein, the unbiased omics and other approaches we...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Petrov, Alexey M., Mast, Natalia, Li, Yong, Pikuleva, Irina A.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662980/
https://ncbi.nlm.nih.gov/pubmed/31063705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900092R
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