The key genes, phosphoproteins, processes, and pathways affected by efavirenz-activated CYP46A1 in the amyloid-decreasing paradigm of efavirenz treatment

Efavirenz (EFV) is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is the major brain cholesterol hydroxylase. Previously, we discovered that EFV activates CYP46A1 and improves behavioral performance in 5XFAD mice, an Alzheimer’s disease model. Herein, the unbiased omics and other approaches we...

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Veröffentlicht in:FASEB J
Hauptverfasser: Petrov, Alexey M., Mast, Natalia, Li, Yong, Pikuleva, Irina A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662980/
https://ncbi.nlm.nih.gov/pubmed/31063705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900092R
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