Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro

BACKGROUND: Oxymatrine (OMT), a quinolizidine alkaloid derived from the traditional Chinese herb Radix Sophorae flavescentis, has widely reported pharmacological efficacy in treating cardiovascular dysfunction-related diseases. However, the underlying mechanism has been unclear. Here, we investigate...

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Bibliografische gegevens
Gepubliceerd in:Med Sci Monit
Hoofdauteurs: Yang, Yu, Chen, Shiping, Tao, Ling, Gan, Shiquan, Luo, Hong, Xu, Yini, Shen, Xiangchun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: International Scientific Literature, Inc. 2019
Onderwerpen:
Lab/In Vitro Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662943/
https://ncbi.nlm.nih.gov/pubmed/31325292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.915542
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