Oxymatrine inhibits aldosterone-induced rat cardiac fibroblast proliferation and differentiation by attenuating smad-2,-3 and-4 expression: an in vitro study

BACKGROUND: We previously demonstrated oxymatrine, an alkaloid from the Chinese medicine radix Sophorae flavescentis, ameliorates hemodynamic disturbances and cardiac fibrosis; however, the underlying mechanisms are unclear. Here, we investigated the effect and mechanism of action of oxymatrine on a...

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Detalhes bibliográficos
Publicado no:BMC Complement Altern Med
Main Authors: Fu, Lingyun, Xu, Yini, Tu, Ling, Huang, Haifeng, Zhang, Yanyan, Chen, Yan, Tao, Ling, Shen, Xiangchun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960670/
https://ncbi.nlm.nih.gov/pubmed/27457615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12906-016-1231-9
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