Inhibitory effects of oxymatrine on TGF-β1-induced proliferation and abnormal differentiation in rat cardiac fibroblasts via the p38MAPK and ERK1/2 signaling pathways

Interstitial fibrosis serves a causal role in the development of heart failure following acute and chronic myocardial infarction, and anti-fibrotic therapy represents a promising strategy to mitigate this pathological process. Oxymatrine (OMT) exerts a number of pharmacological effects on the cardio...

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Publicat a:Mol Med Rep
Autors principals: Xu, Yini, Xiao, Hai, Luo, Hong, Chen, Yan, Zhang, Yanyan, Tao, Ling, Jiang, Yan, Chen, Yuqi, Shen, Xiangchun
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647068/
https://ncbi.nlm.nih.gov/pubmed/28849213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.7277
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