Modifying PTEN recruitment promotes neuron survival, regeneration, and functional recovery after CNS injury

Phosphatase and tensin homolog (PTEN) regulates apoptosis and axonal growth in the developing and adult central nervous system (CNS). Here, we show that human PTEN C-terminal PDZ interactions play a critical role in neuronal apoptosis and axon regeneration after traumatic CNS injury and stroke, high...

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Udgivet i:Cell Death Dis
Main Authors: Shabanzadeh, Alireza Pirsaraei, D’Onofrio, Philippe Matteo, Magharious, Mark, Choi, Kyung An Brian, Monnier, Philippe Patrick, Koeberle, Paulo Dieter
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662832/
https://ncbi.nlm.nih.gov/pubmed/31358730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1802-z
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