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Evolution and Engineering of Allosteric Regulation in Protein Kinases
Phosphoregulation – in which the addition of a negatively charged phosphate group modulates protein activity – is a common feature of proteins that enables dynamic cellular responses. To understand how new phosphoregulation might be acquired, we mutationally scanned the surface of a prototypical yea...
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| Published in: | Sci Signal |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6662207/ https://ncbi.nlm.nih.gov/pubmed/30401787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aar3250 |
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