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Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis
Control of enzyme allosteric regulation is required to drive metabolic flux toward desired levels. Although the three-dimensional (3D) structures of many enzyme-ligand complexes are available, it is still difficult to rationally engineer an allosterically regulatable enzyme without decreasing its ca...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3395594/ https://ncbi.nlm.nih.gov/pubmed/22807670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002612 |
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