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Hotspots for allosteric regulation on protein surfaces
Recent work indicates a general architecture for proteins in which sparse networks of physically contiguous and co-evolving amino acids underlie basic aspects of structure and function. These networks, termed sectors, are spatially organized such that active sites are linked to many surface sites di...
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Главные авторы: | , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
2011
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3414429/ https://ncbi.nlm.nih.gov/pubmed/22196731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.049 |
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