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Surface Sites for Engineering Allosteric Control in Proteins
Statistical analyses of protein families reveal networks of coevolving amino acids that functionally link distantly positioned functional surfaces. Such linkages suggest a concept for engineering allosteric control into proteins: The intramolecular networks of two proteins could be joined across the...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3071530/ https://ncbi.nlm.nih.gov/pubmed/18927392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1159052 |
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