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Structurally distributed surface sites tune allosteric regulation
Our ability to rationally optimize allosteric regulation is limited by incomplete knowledge of the mutations that tune allostery. Are these mutations few or abundant, structurally localized or distributed? To examine this, we conducted saturation mutagenesis of a synthetic allosteric switch in which...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8324303/ https://ncbi.nlm.nih.gov/pubmed/34132193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.68346 |
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