PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly(l‐Glutamic Acid)‐Combretastatin A4 Conjugate in Metastatic Breast Cancer

Vascular disrupting agents (VDAs) have great potential for cancer treatment. Poly(l‐glutamic acid)‐combretastatin A4 conjugate (PLG‐CA4) is a novel class of VDAs. Though it has notable antitumor activity, it can induce host immune responses that promote tumor growth. Here, PLG‐CA4 induces the polari...

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Detalhes bibliográficos
Publicado no:Adv Sci (Weinh)
Main Authors: Qin, Hanjiao, Yu, Haiyang, Sheng, Jiyao, Zhang, Dawei, Shen, Na, Liu, Linlin, Tang, Zhaohui, Chen, Xuesi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662090/
https://ncbi.nlm.nih.gov/pubmed/31380170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201900327
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