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Adaptation by naïve CD4(+) T cells to self-antigen–dependent TCR signaling induces functional heterogeneity and tolerance
Naïve CD4(+) T cells experience weak T cell receptor (TCR) signals induced by self-peptides presented by MHC II. To investigate how these “basal” TCR signals influence responses to agonist TCR ligand stimulation, we analyzed naïve CD4(+) cells expressing varying amounts of CD5, Ly6C, and Nur77-GFP,...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6660790/ https://ncbi.nlm.nih.gov/pubmed/31285342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904096116 |
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